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Primary Lymphoid Organs to Lymph Node Structural Diagram7Topics
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Introduction to Lymphatic Drainage to Lymph Node Palpability and Right Lymphatic Duct6Topics
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Spleen Structure Overview to Thymus-Related Conditions6Topics
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Components and Mechanism of Immunity to Understanding Immune Privilege4Topics
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MHC I and II: Introduction and Loci to DQ8, DR3, DR49Topics
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Functions of Natural Killer Cells to Major Functions of T Cells3Topics
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T Cell Development: Bone Marrow & Thymus to Regulatory T Cells and Autoimmunity6Topics
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T-cell Activation: Antigen Presentation to B-cell Activation: Co-stimulation, Class Switching, and Maturation4Topics
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Antibody Structure and Function to Antibody Diversity and Specificity4Topics
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Introduction to Immunoglobulin Isotypes to Thymus-Dependent Antigens7Topics
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Introduction to Complement System to Convergence and MAC Formation9Topics
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Early Complement Deficiencies to PNH: Hemolysis & Thrombosis4Topics
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Interleukin-1: Macrophage Secretion and Acute Response to IL-10 and IL-13: Immune Regulation and IgE Production7Topics
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Respiratory Burst Introduction to Interferons Clinical Use & Side Effects5Topics
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T Cell Surface Proteins to Examples of Passive and Active Immunity4Topics
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Live Attenuated Vaccines: Description to mRNA Vaccine8Topics
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Overview of Hypersensitivity Types to Type II: Cellular Dysfunction & Clinical Examples6Topics
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Type III Hypersensitivity: Mechanism & Examples to Type IV Hypersensitivity: Examples & Tests5Topics
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Allergic and Anaphylactic Transfusion Reactions to Delayed Hemolytic Transfusion Reaction5Topics
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Autoantibodies in Neuromuscular and Systemic Diseases to Autoantibodies in Metabolic, Hematologic, and Renal Disorders5Topics
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Bruton's Agammaglobulinemia to Chronic Mucocutaneous Candidiasis7Topics
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Severe Combined Immunodeficiency (SCID) to Chronic Granulomatous Disease7Topics
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Intro to Immunodeficiency & T-Cell Bacterial Infections to Parasitic Infections & Key Deficiency Note5Topics
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Hyperacute Transplant Rejection to Histology of Transplant Rejection5Topics
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Immunosuppressants: Definition and Risks to Sirolimus & Basiliximab: Clinical Aspects5Topics
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Azathioprine to Immunotherapy: Interleukin-2 and Interferons6Topics
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TNF-α Inhibitors: Adalimumab & Infliximab to Omalizumab & Palivizumab: Allergic & Viral7Topics
Autoantibodies in Neuromuscular and Systemic Diseases to Autoantibodies in Metabolic, Hematologic, and Renal Disorders
Content August 26, 2025
Autoantibodies
| AUTOANTIBODY | ASSOCIATED DISORDER |
|---|---|
| Anti-postsynaptic ACh receptor | Myasthenia gravis |
| Anti-presynaptic voltage-gated calcium channel | Lambert-Eaton myasthenic syndrome |
| Anti-β₂ glycoprotein I | Antiphospholipid syndrome |
| Antinuclear (ANA) | Nonspecific screening antibody, often associated with SLE |
| Anticardiolipin, lupus anticoagulant | SLE, antiphospholipid syndrome |
| Anti-dsDNA, anti-Smith | SLE |
| Antihistone | Drug-induced lupus |
| Anti-U1 RNP (ribonucleoprotein) | Mixed connective tissue disease |
| AUTOANTIBODY | ASSOCIATED DISORDER |
|---|---|
| Rheumatoid factor (IgM antibody against IgG Fc region), anti-cyclic citrullinated peptide (anti-CCP, more specific) | Rheumatoid arthritis |
| Anti-Ro/SSA, anti-La/SSB | Sjögren syndrome |
| Anti-Scl-70 (anti-DNA topoisomerase I) | Scleroderma (diffuse) |
| Anticentromere | Limited scleroderma (CREST syndrome) |
| Antisynthetase (eg, anti-Jo-1), anti-SRP, anti-helicase (anti-Mi-2) | Polymyositis, dermatomyositis |
| AUTOANTIBODY | ASSOCIATED DISORDER |
|---|---|
| Antimitochondrial | 1° biliary cholangitis |
| Anti-smooth muscle, anti-liver/kidney microsomal-1 | Autoimmune hepatitis |
| Myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA)/perinuclear ANCA (p-ANCA) | Microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis, ulcerative colitis, 1° sclerosing cholangitis |
| PR3-ANCA/cytoplasmic ANCA (c-ANCA) | Granulomatosis with polyangiitis |
| Anti-phospholipase A₂ receptor | 1° membranous nephropathy |
| AUTOANTIBODY | ASSOCIATED DISORDER |
|---|---|
| Anti-hemidesmosome | Bullous pemphigoid |
| Anti-desmoglein (anti-desmosome) | Pemphigus vulgaris |
| Antithyroglobulin, antithyroid peroxidase (antimicrosomal) | Hashimoto thyroiditis |
| Anti-TSH receptor | Graves disease |
| IgA anti-endomysial, IgA anti-tissue transglutaminase, IgA and IgG deamidated gliadin peptide | Celiac disease |
| AUTOANTIBODY | ASSOCIATED DISORDER |
|---|---|
| Anti-glutamic acid decarboxylase, islet cell cytoplasmic antibodies | Type 1 diabetes mellitus |
| Antiparietal cell, anti-intrinsic factor | Pernicious anemia |
| Anti-glomerular basement membrane | Goodpasture syndrome |
Topics Covered:
- Autoantibodies in Neuromuscular and Systemic Diseases
- Autoantibodies in Rheumatoid Arthritis and Scleroderma
- Autoantibodies in Hepatic, Renal, and Vasculitic Disorders
- Autoantibodies in Dermatologic, Endocrine, and GI Diseases
- Autoantibodies in Metabolic, Hematologic, and Renal Disorders
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