USMLE - Chapter 2 - Immunology
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Primary Lymphoid Organs to Lymph Node Structural Diagram7Topics
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Introduction to Lymphatic Drainage to Lymph Node Palpability and Right Lymphatic Duct6Topics
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Spleen Structure Overview to Thymus-Related Conditions6Topics
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Components and Mechanism of Immunity to Understanding Immune Privilege4Topics
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MHC I and II: Introduction and Loci to DQ8, DR3, DR49Topics
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Functions of Natural Killer Cells to Major Functions of T Cells3Topics
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T Cell Development: Bone Marrow & Thymus to Regulatory T Cells and Autoimmunity6Topics
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T-cell Activation: Antigen Presentation to B-cell Activation: Co-stimulation, Class Switching, and Maturation4Topics
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Antibody Structure and Function to Antibody Diversity and Specificity4Topics
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Introduction to Immunoglobulin Isotypes to Thymus-Dependent Antigens7Topics
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Introduction to Complement System to Convergence and MAC Formation9Topics
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Introduction to Complement System
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Complement Activation Pathways
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Functions of Complement Components (Part 1)
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Functions of Complement Components (Part 2) & Inhibitors
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Overview of Complement Pathways Diagram
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Detail of Classic Pathway
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Detail of Lectin Pathway
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Detail of Alternative Pathway
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Convergence and MAC Formation
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Introduction to Complement System
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Early Complement Deficiencies to PNH: Hemolysis & Thrombosis4Topics
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Interleukin-1: Macrophage Secretion and Acute Response to IL-10 and IL-13: Immune Regulation and IgE Production7Topics
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Interleukin-1: Macrophage Secretion and Acute Response
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IL-6 and TNF-alpha: Inflammation and Systemic Effects
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IL-8 and IL-12: Neutrophil Recruitment and Th1 Differentiation
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IL-2 and IL-3: T Cell Growth and Bone Marrow Support
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Interferon-gamma: Th1 Response and Macrophage Activation
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IL-4 and IL-5: Th2 Response and Antibody Production
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IL-10 and IL-13: Immune Regulation and IgE Production
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Interleukin-1: Macrophage Secretion and Acute Response
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Respiratory Burst Introduction to Interferons Clinical Use & Side Effects5Topics
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T Cell Surface Proteins to Examples of Passive and Active Immunity4Topics
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Live Attenuated Vaccines: Description to mRNA Vaccine8Topics
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Live Attenuated Vaccines: Description
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Live Attenuated Vaccines: Pros, Cons, Examples
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Killed/Inactivated Vaccines: Description & Pros/Cons
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Killed/Inactivated Vaccines: Examples
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Subunit, Recombinant, Polysaccharide, Conjugate Vaccines: Description & Pros/Cons
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Subunit, Recombinant, Polysaccharide, Conjugate Vaccines: Examples
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Toxoid Vaccine
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mRNA Vaccine
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Live Attenuated Vaccines: Description
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Overview of Hypersensitivity Types to Type II: Cellular Dysfunction & Clinical Examples6Topics
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Type III Hypersensitivity: Mechanism & Examples to Type IV Hypersensitivity: Examples & Tests5Topics
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Allergic and Anaphylactic Transfusion Reactions to Delayed Hemolytic Transfusion Reaction5Topics
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Autoantibodies in Neuromuscular and Systemic Diseases to Autoantibodies in Metabolic, Hematologic, and Renal Disorders5Topics
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Bruton's Agammaglobulinemia to Chronic Mucocutaneous Candidiasis7Topics
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Severe Combined Immunodeficiency (SCID) to Chronic Granulomatous Disease7Topics
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Intro to Immunodeficiency & T-Cell Bacterial Infections to Parasitic Infections & Key Deficiency Note5Topics
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Hyperacute Transplant Rejection to Histology of Transplant Rejection5Topics
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Immunosuppressants: Definition and Risks to Sirolimus & Basiliximab: Clinical Aspects5Topics
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Azathioprine to Immunotherapy: Interleukin-2 and Interferons6Topics
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TNF-α Inhibitors: Adalimumab & Infliximab to Omalizumab & Palivizumab: Allergic & Viral7Topics
Introduction to Lymphatic Drainage to Lymph Node Palpability and Right Lymphatic Duct
Content August 26, 2025
Lymphatic drainage associations
#boundingbox
This page provides a detailed overview of lymphatic drainage, illustrating key lymph node clusters, the areas of the body they drain, and associated pathologies. The diagram on the left visually maps these nodes, while the table on the right offers specific details.
Upper Body Lymph Nodes
#boundingbox
Submandibular, Submental Nodes
Drain: Oral cavity, anterior tongue, lower lip.
Pathology: Malignancy and metastasis to the oral cavity.
Deep Cervical Nodes
Drain: Head, neck, oropharynx.
Pathology: Upper respiratory tract infection, infectious mononucleosis, Kawasaki disease, malignancy of head, neck, oropharynx.
Supraclavicular Nodes
Drain: Right hemithorax; Left (Virchow node) left hemithorax, abdomen, pelvis.
Pathology: Malignancies of thorax, abdomen, pelvis.
Thoracic and Axillary Lymph Nodes
#boundingbox
Mediastinal Nodes
Drain: Trachea, esophagus.
Pathology: Pulmonary TB (unilateral hilar), Sarcoidosis (bilateral hilar), Lung cancer, Granulomatous disease.
Hilar Nodes
Drain: Lungs.
Pathology: Lung cancer, Granulomatous disease.
Axillary Nodes
Drain: Upper limb, breast, skin above umbilicus.
Pathology: Mastitis, Metastasis (especially breast cancer).
Abdominal and Upper Limb Lymph Nodes
#boundingbox
Epitrochlear Nodes
Drain: Hand, forearm.
Pathology: Secondary syphilis.
Celiac Nodes
Drain: Liver, stomach, spleen, pancreas, upper duodenum.
Superior Mesenteric Nodes
Drain: Lower duodenum, jejunum, ileum, colon to splenic flexure.
Pathology: Mesenteric lymphadenitis, Inflammatory bowel disease, Celiac disease.
Inferior Mesenteric Nodes
Drain: Colon from splenic flexure to upper rectum.
Periumbilical (Sister Mary Joseph node)
Drain: Abdomen, pelvis.
Pathology: Gastric cancer.
Pelvic and Lower Limb Lymph Nodes
#boundingbox
Para-aortic Nodes
Drain: Pair of testes, ovaries, kidneys, fallopian tubes (uterus).
Pathology: Metastasis.
External Iliac Nodes
Drain: Cervix, vagina (upper third), superior bladder, body of uterus.
Internal Iliac Nodes
Drain: Lower rectum to anal canal (above pectinate line), bladder, vagina (middle third), cervix, prostate.
Pathology: Sexually transmitted infections, Medial foot/leg cellulitis (superficial inguinal).
Superficial Inguinal Nodes
Drain: Anal canal (below pectinate line), skin below umbilicus (except popliteal area), scrotum, vulva, vagina (lower third).
Popliteal (“pop-lateral”) Nodes
Drain: Dorsolateral foot, posterior calf.
Pathology: Lateral foot/leg cellulitis.
Legend and Lymphatic Duct Note
#boundingbox
The diagram uses two symbols:
- ● Palpable lymph node
- ● Nonpalpable lymph node
Important note: The right lymphatic duct drains the right side of the body above the diaphragm into the junction of the right subclavian and internal jugular vein.
Topics Covered:
- Introduction to Lymphatic Drainage
- Head, Neck, and Shoulder Lymphatics
- Chest and Armpit Lymphatics
- Abdominal and Forearm Lymphatics
- Pelvic and Lower Limb Lymphatics
- Lymph Node Palpability and Right Lymphatic Duct